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TM: Trial Disease Milestones

describes observations or activities identified for the trial which are anticipated to occur in the course of the disease under study and which trigger the collection of data.

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TD: Trial Disease Assessment provides information on the protocol-specified disease assessment schedule, and will be used for comparison with the actual occurrence of the efficacy assessments in order to determine whether there was good compliance with the schedule.
Spec Designing An SDTM Spec designing will be explained based on aCRF designing and docs